Multiple Sclerosis (abbreviated MS, also known as disseminated sclerosis orencephalomyelitis disseminata) is a chronic inflammotory demyelinating disease. that affects the central nervous system(CNS).
Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the myelin sheath, the material that surrounds and protects your nerve cells.
Multiple sclerosis attacks neurons, the cells of the brain and spinal cord that carry information, create thought and perception, and allow the brain to control the body. Surrounding and protecting these neurons is a layer of fat, called myelin, which helps neurons carry electrical signals. MS causes gradual destruction of myelin (demyelination) in patches throughout the brain and/or spinal cord. Myelin not only protects nerve fibers, but makes their job possible. When myelin or the nerve fiber is destroyed or damaged, the ability of the nerves to conduct electrical impulses to and from the brain is disrupted, and this produces the various symptoms of MS.
The name multiple sclerosis refers to the multiple scars (or scleroses) on the myelin sheaths. MS results from attacks by an individual’s immune system on his or her own nervous system, and it is therefore categorized as an autoimmune disease.
Multiple sclerosis can take several different forms, with new symptoms occurring in discrete attacks or slowly accruing over time. Between attacks symptoms may resolve completely, but permanent neurologic problems often persist. Although much is known about how MS causes damage, the exact cause of MS remains unknown. MS primarily affects adults, with an age of onset typically between 20 and 40 years, and is more common in women than in men.
Symptoms of Multiple Sclerosis
Individuals with multiple sclerosis may experience a wide variety of symptoms. The initial attacks are often transient, mild (or asymptomatic), and self-limited. They often do not prompt a health care visit and sometimes are only identified in retrospect once the diagnosis has been made based on further attacks. The most common initial symptoms reported are: changes in sensation in the arms, legs or face (33%), complete or partial vision loss (optic neuritis) (16%), weakness (13%), double vision (7%), unsteadiness when walking (5%), and balance problems (3%). Fifteen percent of individuals have multiple symptoms when they first seek medical attention. Most people find their initial MS symptoms occur over a period of hours to weeks. For some people the initial MS attack is preceded by infection, trauma or strenuous physical effort.
Other symptoms and physical findings common in MS are flickering eye movements (nystagmus), speech difficulties, tremor, clumsiness of the hands, abnormal muscle spasms, bladder and bowel difficulties, and sexual dysfunction. Cognitive impairments are also common, such as difficulty performing multiple tasks at once, difficulty following detailed instructions, loss of short term memory, emotional instability, and fatigue. Emotional symptoms are common and can be the normal response to having a debilitating disease or the result of damage to the nerves that generate and control emotions. The most common condition, clinical depression, is a product of both causes. Feelings such as anger, anxiety, frustration, and hopelessness are also common, and suicide is a very real threat.
This damage slows down or blocks messages between the brain and body, leading to the symptoms of MS. MS can cause a variety of symptoms including-
- Changes in sensation (in arms, legs or face). Sensations such as numbness, prickling, or “pins and needles”
- Visual problems (complete or partial vision loss and double vision)—optic neuritis, nystagmus or diplopia.
- Muscle weakness.
- Depression,thinking and memory disturbances.
- Difficulties with coordination and speech.
- Severe fatigue.
- Cognitive impairment.
- Problems with balance (ataxia).
- Overheating, and pain.
- Bladder and bowel difficulties.
- Impaired mobility and disability in more severe cases.
The initial attacks are often transient , mild(asymptomatic) and self limited. The atacks are generally preceeded by infection, trauma or sternous physical activities.
Multiple sclerosis affects neurons, the cells of the brain and spinal cord that carry information, create thought and perception, and allow the brain to control the body. Surrounding and protecting some of these neurons is a fatty layer known as the myelin sheath, which helps neurons carry electrical signals. MS causes gradual destruction of myelin sheath (demyelination) and transection of neuron axons in patches throughout the brain and spinal cord. The name multiple sclerosis refers to the multiple scars (or scleroses) on the myelin sheaths. This scarring causes symptoms which vary widely depending upon which signals are interrupted.
The predominant theory today is that MS results from attacks by an individual’simmune system on the nervous system and it is therefore usually categorized as anautoimmune disease. There is a minority view that MS is not an autoimmune disease, but rather a metabolically dependent neurodegenerative disease. Although much is known about how MS causes damage, its exact cause remains unknown.